If Palestinians were to stop cooperate with Israel on security matters, the current situation in West Bank would quickly become unsustainable. The Palestinians would have to be caged properly, like Gaza is, and the spread of Palestinian dwellings would make feeding them a logistical nightmare, as well as being very labour intensive for Civil Administration that is responsible for occupation of West Bank.
The only option for Israel would be to liquidate smaller villages and hamlets, and concentrate Palestinian population into the larger cantons.
See: Palestinian Archipelago:
Now imagine trying to do this to Iranians (or Russians, or Chinese), or any country that has extremely long history and very strong national identity – it is simply unsustainable, and one needs to just look at Germans war with Russia, or Iraq’s war with Iran to realise that the occupation of these countries is just as impossible as the occupation of Afghanistan, and the installation of a Vichy – like puppet government is always a short term solution.
Attacking Iranians is about fragmentation and destabilisation of Middle East. It is most certainly not in American interest – but it certainly is in Israel’s interest.